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Cork woman, 66, died of organ failure after ‘severe vomiting’ while taking weight loss drug Ozempic, inquest told
A GRANDMOTHER died of total organ failure after severe vomiting while taking weight loss drugs Ozempic and Metformin to control her diabetes, an inquest in Cork heard today.
Breeda O’Donoghue, 66, of West End in Carrigtwohill, Co Cork died on December 9, 2023 at Cork University Hospital having been hospitalised three days earlier.
A family member told Cork Coroner’s Court that Breeda was “fine” and in “good health” until she took Ozempic in a bid to lose weight.
The family appealed for people to be aware of the dangers posed by potential side effects of the weight loss drug which has been hailed as a miracle drug – including excessive vomiting.
The mum-of-two died on December 9, 2023 in the Intensive Care Unit at Cork University Hospital after being rushed there by ambulance after she complained of being very sick three days earlier.
Cork City Coroner Philip Comyn indicated he had been in touch with the HPRA (Health Products Regulatory Authority) in relation to the inquest and would advise them of the details of the case.
He also expressed concerns about members of the public sourcing Ozempic outside of the GP setting including online and Dr Bolster agreed that such practices by members of the public were dangerous in nature.
Assistant State Pathologist Dr Bolster, who carried out an autopsy, said that she tried in vain to get a laboratory to test levels of Ozempic in the blood of Mrs O’Donoghue – having checked both in Ireland and internationally.
She said: “We can’t do levels of Ozempic. No lab in the world could do the levels of Ozempic for me.”
She said that she would like to see such testing carried out and described what had happened to Mrs O’Dongohue as “very rare.”
She said that while she read newspaper reports about court actions being taken in deaths which were possibly linked to Ozempic, there was no “scientific literature on mortality rates of this drug.”
Dr Bolster said that the use of Metformin, a diabetic drug was “less likely” to have been an issue in the case but she was unable to rule it out. The benefits of both drugs were “well recognised” but every drug given to a patient comes with a risk factor.
She added that “gastrointestinal issues” were a “known side effect” of Ozempic and this was a “complex, multi-factorial case.”
The PH level in Mrs O’Donoghue’s blood changed due to profound vomiting impacting her cell activity and leading to total organ failure.
Breeda’s doctor Sushil Ranga who was treating her from 2017 said Breeda was diagnosed with Type two diabetes, and also had osteoarthritis, restless legs and hypertension.
She began taking Metformin after she was prescribed it by her GP in Youghal in 2016.
WEIGHT STRUGGLE
She said: “She was seen on a regular basis and monitored along with blood tests. Her diabetes was very well controlled at this point on medication and diet so she did not require endocrinology.”
Dr Ranga said Breeda was struggling to lose weight through diet and exercise and was “very self conscious.”
The medic said: “Her diabetes was controlled, but she was unable to lose weight. So per protocol, she was started on Ozempic 0.25mg on 19/09/23 and after four weeks the dose was increased to 0.5mg on 19/10/23. She was reviewed on 26/10/23 and her weight had reduced to 85.7kg (13 stone and 6.94 pounds) and her BMI was now 33.4.
“She was very happy and managing well and denied any problems.”
DOSE INCREASED
On October 26, 2023 the dose of Ozempic was increased to 1.0mg.
Dr Ranja said: “She was again reviewed in November and was very happy with the results, denying any problems and said that she was tolerating the medication well.
“Her husband rang on December 6 reporting that she was not well, so I immediately reviewed her in the clinic. On examination she was feeling weak, dehydrated and was generally unwell, so she was immediately sent to A&E via ambulance for further hospital management.”
The inquest heard Brenda died at lunchtime in the Intensive Care Unit on December 9 after various treatments failed to improve her condition. When she presented at hospital she told the registrar that she had “multiple episodes of vomiting every day” having started on Ozempic three months earlier.
LACK OF DATA
She said that she had been unable to keep anything down and that her condition had worsened prior to her hospitalisation.
The cause of death was given as “total organ failure due to profound electrolyte abnormalities” along with other factors.
Coroner Philip Comyn said there was a lack of scientific data because Ozempic was a new drug and the long term effects were not yet known.
But there were risks with every drug and Mrs O’Donoghue was well monitored by her GP. She fell into the category of those who are affected by side effects of medication.
STUDIES ‘NOT IN PLACE YET’
He said: “The literature and scientific studies are not in place yet because Ozempic is a new drug on the market, so it will be some time before we can have a more considered review of Ozempic.
“Dr Bolster tried to get tests carried out to ascertain the level of Ozempic in the blood. The State Laboratory didn’t have the facilities.”
Mr Comyn said he was unaware if such testing is available now and expressed his belief that it is something that should be available going forward.
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